Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_000546.6

p.N288Y

c.862A>T

Surrounding Variants

15 papers

NM_000546.6

p.N288fs

c.862_863fs

9 papers

NM_000546.6

p.N288D

c.862A>G

2 papers

NM_000546.6

p.N288H

c.862A>C

1 paper

NM_000546.6

p.E287insFs

c.861dupG

1 paper

NM_000546.6

p.N288insFs

c.862_863ins7

2 papers

NM_000546.6

p.E287delFs

c.861delC

2 papers

NM_000546.6

p.E286_E287del0

c.856_861del6

1 paper

NM_000546.6

p.R282_N288delins

c.846_862delinsCCCCGGGG

42 papers

NM_000546.6

p.E287D

c.861G>T

13 papers

NM_000546.6

p.E287fs

c.859_860fs

1 paper

NM_000546.6

p.E287_N288insFs

c.861_862ins28

44 papers

NM_000546.6

p.E287D

c.861G>C