Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T284_E287delFs

c.850_860del11

Surrounding Variants

42 papers

NM_000546.6

p.E287D

c.861G>T

13 papers

NM_000546.6

p.E287fs

c.859_860fs

1 paper

NM_000546.6

p.E287_N288insFs

c.861_862ins28

44 papers

NM_000546.6

p.E287D

c.861G>C

3 papers

NM_000546.6

p.E287E

c.861G>A

1 paper

NM_000546.6

p.E286del1

c.856_857delTTC

1 paper

NM_000546.6

p.T284_E287delFs

c.851_860del10

1 paper

NM_000546.6

p.R283_E287Fs

c.848_861delinsAAGAFs

15 papers

NM_000546.6

p.N288fs

c.862_863fs

7 papers

NM_000546.6

p.N288Y

c.862A>T

6 papers

NM_000546.6

p.E287V

c.860A>T

9 papers

NM_000546.6

p.N288D

c.862A>G