Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.E287V

c.860A>T

Surrounding Variants

9 papers

NM_000546.6

p.E287G

c.860A>G

6 papers

NM_000546.6

p.E287A

c.860A>C

3 papers

NM_000546.6

p.E287delFs

c.859delC

64 papers

NM_000546.6

p.E287*

c.859G>T

42 papers

NM_000546.6

p.E287D

c.861G>T

13 papers

NM_000546.6

p.E287fs

c.859_860fs

1 paper

NM_000546.6

p.E287_N288insT

c.859_863ins3

1 paper

NM_000546.6

p.E287_N288insFs

c.861_862ins28

44 papers

NM_000546.6

p.E287D

c.861G>C

10 papers

NM_000546.6

p.E287Q

c.859G>C

48 papers

NM_000546.6

p.E287K

c.859G>A

3 papers

NM_000546.6

p.E287E

c.861G>A