Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

23 papers

NM_000546.6

p.E286D

c.858A>T

Surrounding Variants

1 paper

NM_000546.6

p.E286E

c.858A>G

23 papers

NM_000546.6

p.E286D

c.858A>C

7 papers

NM_000546.6

p.E286fs

c.856_857fs

1 paper

NM_000546.6

p.E286insFs

c.856_857ins19

2 papers

NM_000546.6

p.D281_E286insFs

c.841_857dup17

1 paper

NM_000546.6

p.E286delFs

c.856_857delTC

3 papers

NM_000546.6

p.E285del1

c.853_854delCTC

1 paper

NM_000546.6

p.E285_E286delFs

c.853_857del5

1 paper

NM_000546.6

p.R283_E286delFs

c.848_857del10

2 papers

NM_000546.6

p.R280_E286delFs

c.839_857del19

1 paper

NM_000546.6

p.C277_E286del0

c.831_857del27

64 papers

NM_000546.6

p.E287*

c.859G>T