Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

58 papers

NM_000546.6

p.E286V

c.857A>T

Surrounding Variants

88 papers

NM_000546.6

p.E286G

c.857A>G

36 papers

NM_000546.6

p.E286A

c.857A>C

1 paper

NM_000546.6

p.E286insFs

c.856dupG

1 paper

NM_000546.6

p.E286ins5

c.857_858ins15

1 paper

NM_000546.6

p.E286delins

c.856_857delinsTT

7 papers

NM_000546.6

p.E285delFs

c.855delC

3 papers

NM_000546.6

p.E285_E286delFs

c.853_856del4

2 papers

NM_000546.6

p.R283_E286delFs

c.849_856del8

1 paper

NM_000546.6

p.R283_E286del0

c.848_856del9

70 papers

NM_000546.6

p.E286*

c.856G>T

1 paper

NM_000546.6

p.E286_E287insTT

c.856_860ins6

52 papers

NM_000546.6

p.E286Q

c.856G>C

NM_001126115.2

p.E154Q

c.460G>C