Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.E285delFs

c.854_855delCT

Surrounding Variants

70 papers

NM_000546.6

p.E286*

c.856G>T

1 paper

NM_000546.6

p.E286_E287insTT

c.856_860ins6

52 papers

NM_000546.6

p.E286Q

c.856G>C

NM_001126115.2

p.E154Q

c.460G>C

356 papers

NM_000546.6

p.E286K

c.856G>A

NM_001126115.2

p.E154K

c.460G>A

3 papers

NM_000546.6

p.E285_E286delins

c.855_856delinsAA

1 paper

NM_000546.6

p.E285_E286delins

c.853_856delinsAAAA

1 paper

NM_000546.6

p.T284_E285delFs

c.851_855del5

1 paper

NM_000546.6

p.C277_E285del9

c.829_854del27

7 papers

NM_000546.6

p.E286fs

c.856_857fs

12 papers

NM_000546.6

p.E285D

c.855G>T

9 papers

NM_000546.6

p.E285fs

c.853_854fs

1 paper

NM_000546.6

p.E285insFs

c.854_855insAA