Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_000546.6

p.E285A

c.854A>C

Surrounding Variants

90 papers

NM_000546.6

p.E285V

c.854A>T

15 papers

NM_000546.6

p.E285G

c.854A>G

3 papers

NM_000546.6

p.E285delFs

c.853delC

1 paper

NM_000546.6

p.G279_E285delins

c.835_854delinsCCTTGGGG

1 paper

NM_000546.6

p.A276_E285del0

c.827_853del27

56 papers

NM_000546.6

p.E285*

c.853G>T

12 papers

NM_000546.6

p.E285D

c.855G>T

9 papers

NM_000546.6

p.E285fs

c.853_854fs

1 paper

NM_000546.6

p.E285_E286insA

c.853_857ins3

1 paper

NM_000546.6

p.T284insFs

c.852dupA

1 paper

NM_000546.6

p.E285insFs

c.854_855insAA

32 papers

NM_000546.6

p.E285Q

c.853G>C