Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.T284delFs

c.851delG

NM_001126115.2

p.T152delFs

c.455delG

Surrounding Variants

1 paper

NM_000546.6

p.T284T

c.852A>G

2 papers

NM_000546.6

p.T284T

c.852A>C

1 paper

NM_000546.6

p.R282_T284insFs

c.844_850dup7

21 papers

NM_000546.6

p.T284fs

c.850_851fs

1 paper

NM_000546.6

p.R282_T284delFs

c.844_851del8

2 papers

NM_000546.6

p.P278_T284del0

c.834_851del18

56 papers

NM_000546.6

p.E285*

c.853G>T

1 paper

NM_000546.6

p.E285_E286insA

c.853_857ins3

1 paper

NM_000546.6

p.T284insFs

c.852dupA

32 papers

NM_000546.6

p.E285Q

c.853G>C

526 papers

NM_000546.6

p.E285K

c.853G>A

12 papers

NM_000546.6

p.E285fs

c.853_854fs