Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.D281_R283delFs

c.842_848del7

Surrounding Variants

2 papers

NM_000546.6

p.R283R

c.849C>T

2 papers

NM_000546.6

p.R283R

c.849C>G

2 papers

NM_000546.6

p.R282_R283ins0

c.846_848dupGCG

2 papers

NM_000546.6

p.R282_R283insFs

c.845_848dup4

1 paper

NM_000546.6

p.R283_T284insFs

c.849_850insGC

12 papers

NM_000546.6

p.R283fs

c.847_848fs

3 papers

NM_000546.6

p.R283delFs

c.848delC

3 papers

NM_000546.6

p.R282del1

c.844_845delCCG

1 paper

NM_000546.6

p.R282_R283delFs

c.845_848del4

9 papers

NM_000546.6

p.R283L

c.848G>T

1 paper

NM_000546.6

p.R283insFs

c.848_849insT

1 paper

NM_000546.6

p.R282_R283insFs

c.846_847ins7