Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.R283delFs

c.847delG

Surrounding Variants

9 papers

NM_000546.6

p.R283L

c.848G>T

1 paper

NM_000546.6

p.R283insFs

c.848_849insT

1 paper

NM_000546.6

p.R282_R283insFs

c.846_847ins7

130 papers

NM_000546.6

p.R283P

c.848G>C

100 papers

NM_000546.6

p.R283H

c.848G>A

3 papers

NM_000546.6

p.R280_R283delins

c.838_848delinsCA

165 papers

NM_000546.6

p.R283C

c.847C>T

NM_001126115.2

p.R151C

c.451C>T

2 papers

NM_000546.6

p.R283R

c.849C>T

1 paper

NM_000546.6

p.R283delins

c.847delinsTGGATGT

12 papers

NM_000546.6

p.R283G

c.847C>G

2 papers

NM_000546.6

p.R283R

c.849C>G

5 papers

NM_000546.6

p.R282insFs

c.846dupG