Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R283delins

c.847delinsTGGATGT

Surrounding Variants

165 papers

NM_000546.6

p.R283C

c.847C>T

NM_001126115.2

p.R151C

c.451C>T

12 papers

NM_000546.6

p.R283G

c.847C>G

5 papers

NM_000546.6

p.R282insFs

c.846dupG

1 paper

NM_000546.6

p.R282_R283ins2

c.846_847ins6

2 papers

NM_000546.6

p.R282_R283ins1

c.846_847insGGG

1 paper

NM_000546.6

p.R280_R282ins1

c.838_846dup9

1 paper

NM_000546.6

p.R283insFs

c.847_848ins4

1 paper

NM_000546.6

p.R283_T284insR

c.847_851ins3

13 papers

NM_000546.6

p.R283S

c.847C>A

1 paper

NM_000546.6

p.R283delins

c.847delinsGAGGCGA

6 papers

NM_000546.6

p.R282delFs

c.845delC

2 papers

NM_000546.6

p.R282_R283Fs

c.844_847delinsAGFs