Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.D281insFs

c.843dupC

Surrounding Variants

28 papers

NM_000546.6

p.R282L

c.845G>T

1 paper

NM_000546.6

p.R282insFs

c.845_846insT

1 paper

NM_000546.6

p.R282insFs

c.845_846ins4

1 paper

NM_000546.6

p.R282ins2

c.845_846ins6

1 paper

NM_000546.6

p.R282ins1

c.845_846insTGG

1 paper

NM_000546.6

p.R282insFs

c.845_846ins5

1 paper

NM_000546.6

p.R282insFs

c.845_846ins4

1 paper

NM_000546.6

p.R282insFs

c.844_845ins5

94 papers

NM_000546.6

p.R282P

c.845G>C

123 papers

NM_000546.6

p.R282Q

c.845G>A

1 paper

NM_000546.6

p.R282Fs

c.844_845delinsGTCTCCATCTCTTFs

8 papers

NM_000546.6

p.R282delFs

c.844delG