Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R282R

c.844C>A

Surrounding Variants

17 papers

NM_000546.6

p.R282fs

c.844_845fs

1521 papers

NM_000546.6

p.R282W

c.844C>T

NM_001126115.2

p.R150W

c.448C>T

NM_001276760.3

p.R243W

c.727C>T

183 papers

NM_000546.6

p.R282G

c.844C>G

1 paper

NM_000546.6

p.R282insFs

c.844_845insT

1 paper

NM_000546.6

p.R282ins1

c.844_845insATG

1 paper

NM_000546.6

p.G279_D281insFs

c.837_843dup7

1 paper

NM_000546.6

p.R282_R283insG

c.844_848ins3

1 paper

NM_000546.6

p.R282_R283insCG

c.844_848ins6

1 paper

NM_000546.6

p.R282_R283ins7

c.844_848ins21

1 paper

NM_000546.6

p.R282insFs

c.844_845insA

1 paper

NM_000546.6

p.D281_R282delins

c.843_844delinsTT

2 papers

NM_000546.6

p.D281_R282delins

c.843_844delinsGT