Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R280_D281delFs

c.838_842del5

Surrounding Variants

3 papers

NM_000546.6

p.D281D

c.843C>T

151 papers

NM_000546.6

p.D281E

c.843C>G

NM_001126118.2

p.D242E

c.726C>G

NM_001126115.2

p.D149E

c.447C>G

1 paper

NM_000546.6

p.D281_R282insFs

c.843_844insG

11 papers

NM_000546.6

p.D281fs

c.841_842fs

2 papers

NM_000546.6

p.D281insFs

c.842dupA

1 paper

NM_000546.6

p.R280_D281insFs

c.839_842dup4

153 papers

NM_000546.6

p.D281E

c.843C>A

NM_001126115.2

p.D149E

c.447C>A

1 paper

NM_000546.6

p.D281Fs

c.842_843delinsTFs

1 paper

NM_000546.6

p.D281delFs

c.842delT

2 papers

NM_000546.6

p.D281delFs

c.841_842delTC

1 paper

NM_000546.6

p.R280_D281delFs

c.839_842del4

1 paper

NM_000546.6

p.G279_D281del0

c.837_842del6