Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R280del1

c.838_839delTCT

Surrounding Variants

119 papers

NM_000546.6

p.D281Y

c.841G>T

1 paper

NM_000546.6

p.D281_R282insC

c.841_845ins3

1 paper

NM_000546.6

p.R280_D281insFs

c.840_841insAA

143 papers

NM_000546.6

p.D281H

c.841G>C

153 papers

NM_000546.6

p.D281N

c.841G>A

11 papers

NM_000546.6

p.D281fs

c.841_842fs

120 papers

NM_000546.6

p.R280S

c.840A>T

76 papers

NM_001126115.2

p.D149V

c.446A>T

NM_000546.6

p.D281V

c.842A>T

194 papers

NM_000546.6

p.D281G

c.842A>G

116 papers

NM_000546.6

p.R280S

c.840A>C

36 papers

NM_000546.6

p.D281A

c.842A>C

3 papers

NM_000546.6

p.D281insFs

c.842_843insG