Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

120 papers

NM_000546.6

p.R280S

c.840A>T

Surrounding Variants

116 papers

NM_000546.6

p.R280S

c.840A>C

1 paper

NM_000546.6

p.R280insFs

c.839dupG

14 papers

NM_000546.6

p.R280fs

c.838_839fs

1 paper

NM_000546.6

p.R280delins

c.839_840delinsCG

2 papers

NM_000546.6

p.R280delFs

c.839delC

1 paper

NM_000546.6

p.R273_R280del0

c.819_839del21

123 papers

NM_000546.6

p.R280I

c.839G>T

119 papers

NM_000546.6

p.D281Y

c.841G>T

1 paper

NM_000546.6

p.D281_R282insC

c.841_845ins3

2 papers

NM_000546.6

p.R280insFs

c.838dupA

1 paper

NM_000546.6

p.R280_D281insFs

c.840_841insAA

313 papers

NM_000546.6

p.R280T

c.839G>C

NM_001126115.2

p.R148T

c.443G>C