Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R280R

c.838A>C

Surrounding Variants

48 papers

NM_000546.6

p.R280*

c.838A>T

212 papers

NM_000546.6

p.R280G

c.838A>G

13 papers

NM_000546.6

p.G279delFs

c.835delC

1 paper

NM_000546.6

p.C277_G279delFs

c.831_837del7

19 papers

NM_000546.6

p.R280fs

c.838_839fs

123 papers

NM_000546.6

p.R280I

c.839G>T

2 papers

NM_000546.6

p.G279G

c.837G>T

12 papers

NM_000546.6

p.G279fs

c.835_836fs

2 papers

NM_000546.6

p.R280insFs

c.838dupA

313 papers

NM_000546.6

p.R280T

c.839G>C

NM_001126115.2

p.R148T

c.443G>C

1 paper

NM_000546.6

p.G279G

c.837G>C

620 papers

NM_000546.6

p.R280K

c.839G>A