Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.G279A

c.836G>C

Surrounding Variants

22 papers

NM_000546.6

p.G279V

c.836G>T

1 paper

NM_000546.6

p.P278_G279insFs

c.832_835dup4

1 paper

NM_000546.6

p.C277_G279insFs

c.831_835dup5

149 papers

NM_000546.6

p.G279E

c.836G>A

NM_001276760.3

p.G240E

c.719G>A

NM_001126115.2

p.G147E

c.440G>A

1 paper

NM_000546.6

p.G279delins

c.835_836delinsAA

1 paper

NM_000546.6

p.C277_G279delFs

c.831_835del5

2 papers

NM_000546.6

p.A276_P278del3

c.826_833del9

1 paper

NM_000546.6

p.C275_G279delFs

c.825_835del11

13 papers

NM_000546.6

p.G279W

c.835G>T

2 papers

NM_000546.6

p.G279G

c.837G>T

3 papers

NM_001276698.3

p.P119insFs

c.357dupT

NM_000546.6

p.P278insFs

c.834dupT

12 papers

NM_000546.6

p.G279fs

c.835_836fs