Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_000546.6

p.G279fs

c.835_836fs

Surrounding Variants

13 papers

NM_000546.6

p.G279W

c.835G>T

3 papers

NM_001276698.3

p.P119insFs

c.357dupT

NM_000546.6

p.P278insFs

c.834dupT

1 paper

NM_000546.6

p.G279insFs

c.835_836insA

38 papers

NM_000546.6

p.G279R

c.835G>C

42 papers

NM_000546.6

p.G279R

c.835G>A

6 papers

NM_000546.6

p.C277_P278del2

c.829_833del6

1 paper

NM_000546.6

p.F270_P278delFs

c.809_834del26

1 paper

NM_000546.6

p.P278insFs

c.833_834insC

1 paper

NM_000546.6

p.A276_P278insFs

c.826_833dup8

14 papers

NM_000546.6

p.P278fs

c.832_833fs

2 papers

NM_000546.6

p.P278P

c.834T>A

15 papers

NM_000546.6

p.P278delFs

c.833delG