Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P278delins

c.832_833delinsAT

Surrounding Variants

240 papers

NM_000546.6

p.P278L

c.833C>T

178 papers

NM_000546.6

p.P278R

c.833C>G

1 paper

NM_000546.6

p.P278insFs

c.833_834insT

2 papers

NM_000546.6

p.C277_P278insFs

c.831_832dupTC

1 paper

NM_000546.6

p.F270_P278insFs

c.808_832dup25

77 papers

NM_000546.6

p.P278H

c.833C>A

5 papers

NM_000546.6

p.P278delins

c.832_833delinsTT

1 paper

NM_000546.6

p.R267_C277del11

c.799_830del33

2 papers

NM_000546.6

p.N263_P278Fs

c.789_833delinsCCCTFs

1 paper

NM_000546.6

p.P278insFs

c.833_834insC

1 paper

NM_000546.6

p.A276_P278insFs

c.826_833dup8

14 papers

NM_000546.6

p.P278fs

c.832_833fs