Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

357 papers

NM_000546.6

p.P278S

c.832C>T

Surrounding Variants

12 papers

NM_000546.6

p.P278fs

c.832_833fs

150 papers

NM_000546.6

p.P278A

c.832C>G

1 paper

NM_000546.6

p.C277insFs

c.831dupT

111 papers

NM_000546.6

p.P278T

c.832C>A

1 paper

NM_000546.6

p.C277delFs

c.831delA

1 paper

NM_000546.6

p.C277delFs

c.830_831delAC

2 papers

NM_000546.6

p.C277del1

c.829_830delACA

3 papers

NM_000546.6

p.A276_C277del0

c.826_831del6

1 paper

NM_000546.6

p.C275_P278delins

c.825_832delinsAGGTG

1 paper

NM_000546.6

p.V274_C277delFs

c.822_831del10

1 paper

NM_000546.6

p.C277insFs

c.830dupG

1 paper

NM_000546.6

p.A276_C277ins0

c.828_830dupCTG