Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.C277delFs

c.830delC

Surrounding Variants

1 paper

NM_000546.6

p.C277insFs

c.830dupG

1 paper

NM_000546.6

p.A276_C277ins0

c.828_830dupCTG

9 papers

NM_000546.6

p.C277fs

c.829_830fs

23 papers

NM_000546.6

p.C277W

c.831T>G

2 papers

NM_000546.6

p.C277C

c.831T>C

31 papers

NM_000546.6

p.C277*

c.831T>A

2 papers

NM_000546.6

p.A276_C277delFs

c.827_830del4

1 paper

NM_000546.6

p.A276_C277delFs

c.826_830del5

12 papers

NM_000546.6

p.P278fs

c.832_833fs

238 papers

NM_000546.6

p.C277F

c.830G>T

NM_001126115.2

p.C145F

c.434G>T

2 papers

NM_000546.6

p.C277insFs

c.829_830insT

1 paper

NM_000546.6

p.C277insFs

c.830_831ins19