Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.A276delFs

c.827_828delGG

Surrounding Variants

1 paper

NM_000546.6

p.C277_P278insC

c.829_833ins3

1 paper

NM_000546.6

p.C277_P278ins10

c.829_833ins30

36 papers

NM_000546.6

p.C277G

c.829T>G

19 papers

NM_000546.6

p.C277R

c.829T>C

18 papers

NM_000546.6

p.C277S

c.829T>A

5 papers

NM_000546.6

p.C277fs

c.829_830fs

6 papers

NM_000546.6

p.A276delFs

c.828delG

1 paper

NM_000546.6

p.R273_A276del4

c.817_827del12

238 papers

NM_000546.6

p.C277F

c.830G>T

NM_001126115.2

p.C145F

c.434G>T

2 papers

NM_000546.6

p.C277insFs

c.829_830insT

1 paper

NM_000546.6

p.C277insFs

c.830_831ins19

1 paper

NM_000546.6

p.C277insFs

c.830_831insA