Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.A276delins

c.826_827delinsAT

Surrounding Variants

33 papers

NM_000546.6

p.A276V

c.827C>T

57 papers

NM_000546.6

p.A276G

c.827C>G

1 paper

NM_000546.6

p.V274_A276ins1

c.821_826dup6

76 papers

NM_000546.6

p.A276D

c.827C>A

1 paper

NM_000546.6

p.A276delins

c.826_827delinsTT

1 paper

NM_000546.6

p.A276delFs

c.826delC

5 papers

NM_000546.6

p.C275_A276delFs

c.825_826delCA

1 paper

NM_000546.6

p.C275_A276del1

c.824_826delCAC

1 paper

NM_000546.6

p.C275_A276delFs

c.823_826del4

1 paper

NM_000546.6

p.V274_A276del0

c.821_826del6

1 paper

NM_000546.6

p.E271_A276del0

c.812_826del15

18 papers

NM_000546.6

p.A276S

c.826G>T

NM_001126115.2

p.C143_A144delins

c.429_430delinsTT