Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

67 papers

NM_000546.6

p.A276P

c.826G>C

Surrounding Variants

18 papers

NM_000546.6

p.A276S

c.826G>T

NM_001126115.2

p.C143_A144delins

c.429_430delinsTT

1 paper

NM_000546.6

p.V274_C275insFs

c.822_825dup4

1 paper

NM_000546.6

p.S269_C275ins2

c.805_825dup21

1 paper

NM_000546.6

p.A276_C277insC

c.826_830ins3

37 papers

NM_000546.6

p.A276T

c.826G>A

1 paper

NM_000546.6

p.C275delFs

c.825delA

1 paper

NM_000546.6

p.N268_C275delFs

c.804_825del22

15 papers

NM_000546.6

p.A276fs

c.826_827fs

1 paper

NM_000546.6

p.C275insFs

c.824dupG

16 papers

NM_000546.6

p.C275fs

c.823_824fs

1 paper

NM_000546.6

p.C275_A276insFs

c.825_826insA

42 papers

NM_000546.6

p.C275W

c.825T>G