Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.V274delFs

c.822delA

Surrounding Variants

204 papers

NM_000546.6

p.C275F

c.824G>T

8 papers

NM_000546.6

p.C275insFs

c.823dupT

1 paper

NM_000546.6

p.C275ins1

c.823_824insTAC

1 paper

NM_000546.6

p.C275insFs

c.824_825ins8

1 paper

NM_000546.6

p.C275ins6

c.824_825ins18

54 papers

NM_000546.6

p.C275S

c.824G>C

NM_001276698.3

p.C116S

c.347G>C

338 papers

NM_000546.6

p.C275Y

c.824G>A

NM_001276697.3

p.C116Y

c.347G>A

1 paper

NM_000546.6

p.V274_C275del1

c.821_823delAAA

1 paper

NM_000546.6

p.V274ins0

c.820_822dupGTT

1 paper

NM_000546.6

p.V274_C275insFs

c.822_823insTG

1 paper

NM_000546.6

p.C275insFs

c.824dupG

16 papers

NM_000546.6

p.C275fs

c.823_824fs