Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.V274_C275insFs

c.822_823insTG

Surrounding Variants

1 paper

NM_000546.6

p.V274ins0

c.820_822dupGTT

1 paper

NM_000546.6

p.C275_A276insVC

c.823_827ins6

1 paper

NM_000546.6

p.C275_A276ins4

c.823_827ins12

50 papers

NM_000546.6

p.C275G

c.823T>G

87 papers

NM_000546.6

p.C275R

c.823T>C

50 papers

NM_000546.6

p.C275S

c.823T>A

NM_001276698.3

p.C116S

c.346T>A

1 paper

NM_000546.6

p.R273_V274del2

c.817_821del6

14 papers

NM_000546.6

p.C275fs

c.823_824fs

14 papers

NM_000546.6

p.V274fs

c.820_821fs

3 papers

NM_000546.6

p.V274V

c.822T>G

3 papers

NM_000546.6

p.V274V

c.822T>A

6 papers

NM_000546.6

p.V274delFs

c.820_821delAC