Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

67 papers

NM_000546.6

p.V274G

c.821T>G

Surrounding Variants

1 paper

NM_000546.6

p.R273insFs

c.818_819ins5

91 papers

NM_000546.6

p.V274A

c.821T>C

NM_001126115.2

p.V142A

c.425T>C

65 papers

NM_000546.6

p.V274D

c.821T>A

3 papers

NM_000546.6

p.V274delFs

c.820delC

1 paper

NM_000546.6

p.V274delins

c.820_821delinsAG

1 paper

NM_000546.6

p.E271_V274del0

c.812_820del9

14 papers

NM_000546.6

p.V274fs

c.820_821fs

3 papers

NM_000546.6

p.V274V

c.822T>G

3 papers

NM_000546.6

p.V274V

c.822T>A

6 papers

NM_000546.6

p.V274delFs

c.820_821delAC

6 papers

NM_000546.6

p.V274fs

c.820_821fs

234 papers

NM_000546.6

p.V274F

c.820G>T