Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.F270_R273delFs

c.810_819del10

Surrounding Variants

6 papers

NM_000546.6

p.V274fs

c.820_821fs

234 papers

NM_000546.6

p.V274F

c.820G>T

4 papers

NM_000546.6

p.V274insFs

c.820_821insT

1 paper

NM_000546.6

p.R273ins6

c.818_819ins18

54 papers

NM_000546.6

p.V274L

c.820G>C

19 papers

NM_000546.6

p.V274I

c.820G>A

2 papers

NM_000546.6

p.R273_V274delins

c.818_821delinsTTTT

1 paper

NM_000546.6

p.N263_R273del11

c.787_818del33

1 paper

NM_000546.6

p.R273insFs

c.818_819ins5

16 papers

NM_000546.6

p.R273fs

c.817_818fs

67 papers

NM_000546.6

p.V274G

c.821T>G

91 papers

NM_000546.6

p.V274A

c.821T>C

NM_001126115.2

p.V142A

c.425T>C