Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.R273Fs

c.817_819delinsGGFs

Surrounding Variants

16 papers

NM_000546.6

p.R273fs

c.817_818fs

4 papers

NM_000546.6

p.R273R

c.819T>C

1 paper

NM_000546.6

p.R273R

c.819T>A

3 papers

NM_000546.6

p.R273delFs

c.818delC

1 paper

NM_000546.6

p.R273delins

c.818_819delinsAG

1 paper

NM_000546.6

p.R273delins

c.818_819delinsAA

1 paper

NM_000546.6

p.E271_R273delFs

c.811_818del8

1 paper

NM_000546.6

p.R267_R273del0

c.801_818del18

6 papers

NM_000546.6

p.V274fs

c.820_821fs

541 papers

NM_000546.6

p.R273L

c.818G>T

NM_001126116.2

p.R141L

c.422G>T

234 papers

NM_000546.6

p.V274F

c.820G>T

4 papers

NM_000546.6

p.V274insFs

c.820_821insT