Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.F270_R273delFs

c.808_817del10

Surrounding Variants

541 papers

NM_000546.6

p.R273L

c.818G>T

NM_001126116.2

p.R141L

c.422G>T

1 paper

NM_000546.6

p.R273ins1

c.818_819insCTT

1 paper

NM_000546.6

p.R273insFs

c.817dupC

2 papers

NM_000546.6

p.V272_R273ins0

c.815_817dupTGC

164 papers

NM_000546.6

p.R273P

c.818G>C

3219 papers

NM_000546.6

p.R273H

c.818G>A

NM_001126115.2

p.R141H

c.422G>A

NM_001276760.3

p.R234H

c.701G>A

1 paper

NM_000546.6

p.R273delins

c.817_818delinsAT

1 paper

NM_000546.6

p.R273delFs

c.817delG

2 papers

NM_000546.6

p.R273delins

c.817_818delinsTA

1 paper

NM_000546.6

p.V272_R273Fs

c.815_818delinsCAFs

16 papers

NM_000546.6

p.R273fs

c.817_818fs

4 papers

NM_000546.6

p.R273R

c.819T>C