Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.R273fs

c.817_818fs

Surrounding Variants

1706 papers

NM_000546.6

p.R273C

c.817C>T

NM_001126115.2

p.R141C

c.421C>T

120 papers

NM_000546.6

p.R273G

c.817C>G

1 paper

NM_000546.6

p.V272_R273insFs

c.816_817insGG

1 paper

NM_000546.6

p.V272_R273insFs

c.816_817ins5

1 paper

NM_000546.6

p.R273insFs

c.817_818insA

142 papers

NM_000546.6

p.R273S

c.817C>A

NM_001126115.2

p.R141S

c.421C>A

2 papers

NM_000546.6

p.V272delFs

c.815_816delCA

1 paper

NM_000546.6

p.V272del1

c.814_816delCAC

1 paper

NM_000546.6

p.E271_V272delFs

c.812_816del5

1 paper

NM_000546.6

p.G266_V272del7

c.796_815del21

1 paper

NM_000546.6

p.G262_V272del11

c.784_815del33

541 papers

NM_000546.6

p.R273L

c.818G>T

NM_001126116.2

p.R141L

c.422G>T