Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.E271_V272insFs

c.812_815dup4

Surrounding Variants

1 paper

NM_000546.6

p.V272insFs

c.815dupT

7 papers

NM_000546.6

p.V272fs

c.814_815fs

1 paper

NM_000546.6

p.V272V

c.816G>C

4 papers

NM_000546.6

p.V272V

c.816G>A

1 paper

NM_000546.6

p.G266_V272del0

c.798_815del18

1 paper

NM_000546.6

p.L264_V272del0

c.792_815del24

1 paper

NM_000546.6

p.V272insFs

c.814_815insG

1 paper

NM_000546.6

p.V272ins6

c.814_815ins18

60 papers

NM_000546.6

p.V272G

c.815T>G

27 papers

NM_000546.6

p.V272A

c.815T>C

46 papers

NM_000546.6

p.V272E

c.815T>A

6 papers

NM_000546.6

p.V272delFs

c.814delC