Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E271_V272delins

c.813_814delinsAT

Surrounding Variants

228 papers

NM_000546.6

p.V272L

c.814G>T

NM_001276760.3

p.V233L

c.697G>T

1 paper

NM_000546.6

p.V272Fs

c.814delinsCTTFs

219 papers

NM_000546.6

p.V272L

c.814G>C

NM_001276760.3

p.V233L

c.697G>C

419 papers

NM_000546.6

p.V272M

c.814G>A

5 papers

NM_000546.6

p.V272fs

c.814_815fs

1 paper

NM_000546.6

p.E271_V272delins

c.813_814delinsTA

1 paper

NM_000546.6

p.E271_V272delins

c.813_814delinsAA

1 paper

NM_000546.6

p.E271delFs

c.812_813delCT

1 paper

NM_000546.6

p.V272insFs

c.814_815insG

1 paper

NM_000546.6

p.V272ins6

c.814_815ins18

60 papers

NM_000546.6

p.V272G

c.815T>G

27 papers

NM_000546.6

p.V272A

c.815T>C