Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.E271A

c.812A>C

Surrounding Variants

55 papers

NM_000546.6

p.E271V

c.812A>T

13 papers

NM_000546.6

p.E271G

c.812A>G

1 paper

NM_000546.6

p.E271delins

c.811_812delinsTT

1 paper

NM_000546.6

p.E271delFs

c.811delC

1 paper

NM_000546.6

p.S269_E271del0

c.806_811del6

2 papers

NM_000546.6

p.G266_F270del5

c.796_809del15

1 paper

NM_000546.6

p.S261_F270del0

c.783_809del27

54 papers

NM_000546.6

p.E271*

c.811G>T

15 papers

NM_000546.6

p.E271D

c.813G>T

4 papers

NM_000546.6

p.F270insFs

c.810dupT

1 paper

NM_000546.6

p.F270insFs

c.809_810dupTT

7 papers

NM_000546.6

p.E271fs

c.811_812fs