Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

150 papers

NM_000546.6

p.E271K

c.811G>A

NM_001126115.2

p.E139K

c.415G>A

Surrounding Variants

54 papers

NM_000546.6

p.E271*

c.811G>T

4 papers

NM_000546.6

p.F270insFs

c.810dupT

1 paper

NM_000546.6

p.F270insFs

c.809_810dupTT

1 paper

NM_000546.6

p.E271_V272insT

c.811_815ins3

1 paper

NM_000546.6

p.E271_V272insTA

c.811_815ins6

52 papers

NM_000546.6

p.E271Q

c.811G>C

3 papers

NM_000546.6

p.F270delFs

c.808delA

1 paper

NM_000546.6

p.F270_E271delins

c.810_811delinsAA

3 papers

NM_000546.6

p.F270del1

c.808_809delAAA

1 paper

NM_000546.6

p.R267_F270del4

c.799_809del12

2 papers

NM_000546.6

p.E271fs

c.811_812fs

1 paper

NM_000546.6

p.N268_F270ins1

c.804_809dup6