Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.F270insFs

c.809_810ins19

Surrounding Variants

1 paper

NM_000546.6

p.N268_F270ins1

c.804_809dup6

8 papers

NM_000546.6

p.F270fs

c.808_809fs

107 papers

NM_000546.6

p.F270L

c.810T>G

107 papers

NM_000546.6

p.F270L

c.810T>A

1 paper

NM_000546.6

p.S269_F270del1

c.807_809delAAG

2 papers

NM_000546.6

p.L265_F270del0

c.795_809del15

1 paper

NM_000546.6

p.G262_F270delFs

c.784_809del26

76 papers

NM_000546.6

p.F270C

c.809T>G

105 papers

NM_000546.6

p.F270S

c.809T>C

10 papers

NM_000546.6

p.F270Y

c.809T>A

1 paper

NM_000546.6

p.F270delins

c.808_809delinsCA

2 papers

NM_000546.6

p.S269_F270del1

c.806_808delAGC