Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.R267fs

c.799_800fs

Surrounding Variants

242 papers

NM_000546.6

p.R267W

c.799C>T

31 papers

NM_000546.6

p.R267G

c.799C>G

1 paper

NM_000546.6

p.G266_R267insFs

c.798_799insA

3 papers

NM_000546.6

p.R267R

c.799C>A

2 papers

NM_000546.6

p.G266delFs

c.798delT

17 papers

NM_000546.6

p.R267L

c.800G>T

102 papers

NM_000546.6

p.R267P

c.800G>C

111 papers

NM_000546.6

p.R267Q

c.800G>A

NM_001126115.2

p.R135Q

c.404G>A

4 papers

NM_000546.6

p.G266_R267delFs

c.798_799delGT

2 papers

NM_000546.6

p.L265_R267del0

c.794_799del6

2 papers

NM_000546.6

p.G266G

c.798A>T

1 paper

NM_000546.6

p.G266_R267insFs

c.798_799insGG