Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L265_G266del1

c.794_796delCCA

Surrounding Variants

198 papers

NM_000546.6

p.G266V

c.797G>T

7 papers

NM_000546.6

p.G266A

c.797G>C

299 papers

NM_000546.6

p.G266E

c.797G>A

NM_001126115.2

p.G134E

c.401G>A

1 paper

NM_000546.6

p.G266delins

c.796_797delinsTT

1 paper

NM_000546.6

p.G266delins

c.796_797delinsAA

1 paper

NM_000546.6

p.L264_G266delFs

c.792_796del5

1 paper

NM_000546.6

p.L264_G266delFs

c.790_796del7

87 papers

NM_000546.6

p.G266*

c.796G>T

1 paper

NM_000546.6

p.G266_R267insLG

c.796_800ins6

1 paper

NM_000546.6

p.G266insFs

c.796_797insA

253 papers

NM_000546.6

p.G266R

c.796G>C

259 papers

NM_000546.6

p.G266R

c.796G>A