Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

14 papers

NM_000546.6

p.L265Q

c.794T>A

Surrounding Variants

44 papers

NM_000546.6

p.L265R

c.794T>G

130 papers

NM_000546.6

p.L265P

c.794T>C

1 paper

NM_000546.6

p.L265delFs

c.793delG

1 paper

NM_000546.6

p.L265L

c.795G>T

4 papers

NM_000546.6

p.L265fs

c.793_794fs

2 papers

NM_000546.6

p.L265L

c.795G>A

1 paper

NM_000546.6

p.L265delins

c.794_795delinsCT

1 paper

NM_000546.6

p.L265delFs

c.794delA

9 papers

NM_000546.6

p.L265fs

c.793_794fs

20 papers

NM_000546.6

p.L264_L265del1

c.792_794delAGT

1 paper

NM_000546.6

p.L264_L265delFs

c.791_794del4

1 paper

NM_000546.6

p.N263_L265del0

c.789_794del6