Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.N263fs

c.787_788fs

Surrounding Variants

5 papers

NM_000546.6

p.N263Y

c.787A>T

30 papers

NM_000546.6

p.N263D

c.787A>G

12 papers

NM_000546.6

p.N263H

c.787A>C

1 paper

NM_000546.6

p.G262insFs

c.785_786ins20

2 papers

NM_000546.6

p.G262delFs

c.786delA

18 papers

NM_000546.6

p.G262del1

c.784_785delACC

2 papers

NM_000546.6

p.S261_G262delFs

c.783_786del4

12 papers

NM_000546.6

p.G262fs

c.784_785fs

4 papers

NM_000546.6

p.G262G

c.786T>C

1 paper

NM_000546.6

p.G262G

c.786T>A

15 papers

NM_000546.6

p.G262delFs

c.785delC

NM_001126118.2

p.G223delFs

c.784delC

1 paper

NM_000546.6

p.G262delins

c.785_786delinsTA