Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

50 papers

NM_000546.6

p.S261Splc

c.783-1G>T

Surrounding Variants

21 papers

NM_000546.6

p.S261T

c.782G>C

50 papers

NM_000546.6

p.S261Splc

c.783-1G>A

9 papers

NM_000546.6

p.S261R

c.783T>G

2 papers

NM_000546.6

p.S261S

c.783T>C

10 papers

NM_000546.6

p.S261R

c.783T>A

24 papers

NM_000546.6

p.S261Splc

c.783-2A>T

26 papers

NM_000546.6

p.S261Splc

c.783-2A>G

28 papers

NM_000546.6

p.S261Splc

c.783-2A>C

NM_001126118.2

p.S261R

c.781A>C

15 papers

NM_000546.6

p.G262fs

c.784_785fs

11 papers

NM_000546.6

p.G262C

c.784G>T

1 paper

NM_000546.6

p.S261_G262insFs

c.783_784ins17

4 papers

NM_000546.6

p.G262R

c.784G>C