Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S261Splc

c.783-8C>G

Surrounding Variants

1 paper

NM_000546.6

p.S261Splc

c.783-9C>T

1 paper

NM_000546.6

p.S261Splc

c.783-10T>G

1 paper

NM_000546.6

p.S261Splc

c.783-6G>T

1 paper

NM_000546.6

p.S261Splc

c.783-6G>C

2 papers

NM_000546.6

p.S261Splc

c.783-11A>G

1 paper

NM_000546.6

p.S261Splc

c.783-12T>C

3 papers

NM_000546.6

p.S261Splc

c.783-4G>A

1 paper

NM_000546.6

p.S261Splc

c.783-13C>T

1 paper

NM_000546.6

p.S261Splc

c.783-13C>G

1 paper

NM_000546.6

p.S261Splc

c.783-14C>T

24 papers

NM_000546.6

p.S261Splc

c.783-2A>T

26 papers

NM_000546.6

p.S261Splc

c.783-2A>G