Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S261Splc

c.782+3C>T

Surrounding Variants

1 paper

NM_000546.6

p.S261Splc

c.782+3C>A

21 papers

NM_000546.6

p.S261Splc

c.782+2T>G

4 papers

NM_000546.6

p.S261Splc

c.782+2T>C

6 papers

NM_000546.6

p.S261Splc

c.782+2T>A

47 papers

NM_000546.6

p.S261Splc

c.782+1G>T

8 papers

NM_000546.6

p.S261Splc

c.782+1G>C

1 paper

NM_000546.6

p.S261Splc

c.782+5G>C

68 papers

NM_000546.6

p.S261Splc

c.782+1G>A

2 papers

NM_000546.6

p.D259_S261del0

c.777_782del6

1 paper

NM_000546.6

p.E258_S261delFs

c.773_782del10

5 papers

NM_000546.6

p.S261I

c.782G>T

1 paper

NM_000546.6

p.S261ins1

c.782_783insTAT