Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.S261delFs

c.781delT

Surrounding Variants

5 papers

NM_000546.6

p.S261I

c.782G>T

1 paper

NM_000546.6

p.S261ins1

c.782_783insTAT

1 paper

NM_000546.6

p.S261insFs

c.781_782insA

1 paper

NM_000546.6

p.S260_S261insFs

c.778_781dup4

1 paper

NM_000546.6

p.L257_S261insFs

c.769_781dup13

9 papers

NM_000546.6

p.S261T

c.782G>C

7 papers

NM_000546.6

p.S261N

c.782G>A

1 paper

NM_000546.6

p.D259_S261delFs

c.777_781del5

1 paper

NM_000546.6

p.L257_S261delFs

c.769_781del13

1 paper

NM_000546.6

p.T256_S261del0

c.767_781del15

1 paper

NM_000546.6

p.T253_S260del8

c.757_779del24

47 papers

NM_000546.6

p.S261Splc

c.782+1G>T