Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.D259insFs

c.775_776insG

Surrounding Variants

81 papers

NM_000546.6

p.D259V

c.776A>T

27 papers

NM_000546.6

p.D259G

c.776A>G

NM_001126118.2

p.D220G

c.659A>G

8 papers

NM_000546.6

p.D259A

c.776A>C

1 paper

NM_000546.6

p.L257_D259delFs

c.771_775del5

1 paper

NM_000546.6

p.L257_D259del0

c.770_775del6

132 papers

NM_000546.6

p.D259Y

c.775G>T

2 papers

NM_000546.6

p.E258_D259insFs

c.774_775insA

1 paper

NM_000546.6

p.D259insFs

c.775_776ins8

1 paper

NM_000546.6

p.I251_E258insFs

c.753_774dup22

18 papers

NM_000546.6

p.D259H

c.775G>C

31 papers

NM_000546.6

p.D259N

c.775G>A

2 papers

NM_000546.6

p.E258delFs

c.774delT