Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.E258fs

c.772_773fs

Surrounding Variants

74 papers

NM_000546.6

p.E258D

c.774A>T

1 paper

NM_000546.6

p.E258E

c.774A>G

74 papers

NM_000546.6

p.E258D

c.774A>C

1 paper

NM_001276760.3

p.E219_D220insFs

c.657_658insTA

1 paper

NM_000546.6

p.E258delins

c.772_774delinsCCT

1 paper

NM_000546.6

p.I255_E258delFs

c.763_772del10

1 paper

NM_000546.6

p.L252_E258del0

c.756_773del18

1 paper

NM_000546.6

p.L252_E258delFs

c.755_773del19

132 papers

NM_000546.6

p.D259Y

c.775G>T

2 papers

NM_000546.6

p.E258_D259insFs

c.774_775insA

1 paper

NM_000546.6

p.D259insFs

c.775_776ins8

1 paper

NM_000546.6

p.I251_E258insFs

c.753_774dup22