Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.E258insFs

c.772dupG

Surrounding Variants

33 papers

NM_000546.6

p.E258V

c.773A>T

77 papers

NM_000546.6

p.E258G

c.773A>G

40 papers

NM_000546.6

p.E258A

c.773A>C

1 paper

NM_000546.6

p.E258delins

c.772_773delinsTT

3 papers

NM_000546.6

p.E258delFs

c.772delC

1 paper

NM_000546.6

p.P250_E258delFs

c.750_772del23

82 papers

NM_000546.6

p.E258*

c.772G>T

1 paper

NM_000546.6

p.E258_D259insGTG

c.772_776ins9

46 papers

NM_000546.6

p.E258Q

c.772G>C

225 papers

NM_000546.6

p.E258K

c.772G>A

1 paper

NM_000546.6

p.L257_E258delins

c.771_772delinsAA

2 papers

NM_000546.6

p.L257delFs

c.770_771delCA