Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.I255_T256delFs

c.764_768del5

Surrounding Variants

15 papers

NM_000546.6

p.L257fs

c.769_770fs

4 papers

NM_000546.6

p.L257L

c.769C>T

26 papers

NM_000546.6

p.L257V

c.769C>G

1 paper

NM_000546.6

p.L257insFs

c.769_770ins7

1 paper

NM_000546.6

p.L257_E258insTA

c.769_773ins6

1 paper

NM_000546.6

p.T256_L257insFs

c.768_769insAG

3 papers

NM_000546.6

p.L257M

c.769C>A

3 papers

NM_000546.6

p.T256delFs

c.768delT

4 papers

NM_000546.6

p.T256del1

c.766_767delTGT

3 papers

NM_000546.6

p.I255_T256del2

c.763_767del6

1 paper

NM_000546.6

p.L257insFs

c.769dupC

46 papers

NM_000546.6

p.L257R

c.770T>G