Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

18 papers

NM_000546.6

p.T256fs

c.766_767fs

Surrounding Variants

3 papers

NM_000546.6

p.T256T

c.768A>T

7 papers

NM_000546.6

p.T256T

c.768A>G

2 papers

NM_000546.6

p.T256delFs

c.767delG

1 paper

NM_000546.6

p.I255_T256del1

c.765_767delGTG

1 paper

NM_000546.6

p.T253_T256del0

c.759_767del9

1 paper

NM_000546.6

p.G245_T256del0

c.735_767del33

15 papers

NM_000546.6

p.L257fs

c.769_770fs

21 papers

NM_000546.6

p.T256I

c.767C>T

4 papers

NM_000546.6

p.L257L

c.769C>T

26 papers

NM_000546.6

p.L257V

c.769C>G

9 papers

NM_000546.6

p.T256R

c.767C>G

1 paper

NM_000546.6

p.L257insFs

c.769_770ins7